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接種新冠疫苗影響生育?無(wú)稽之談

Kat Eschner
2021-11-09

各項(xiàng)研究表明,影響生育這個(gè)荒誕說(shuō)法是人們不愿意接種新冠疫苗的主要原因。

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11月5日,綠灣包裝工隊(duì)(Green Bay Packers)的四分衛(wèi)阿隆·羅杰斯告訴《帕特·麥卡菲秀》(Pat McAfee Show),他因?yàn)閾?dān)心患上不孕癥而拒絕接種新冠疫苗,由此他成為最近公開(kāi)表示擔(dān)心新冠疫苗接種和不育癥問(wèn)題的名人。羅杰斯說(shuō):“我相信,我人生的下一個(gè)重要篇章是成為一名父親,所以我對(duì)這件事情非常重視?!?/p>

羅杰斯并不是唯一有這種擔(dān)憂的人,但這并不意味著他的想法是對(duì)的。在這場(chǎng)為期近一年的新冠疫苗接種運(yùn)動(dòng)中,新冠疫苗影響生育能力的荒誕說(shuō)法是持續(xù)時(shí)間最久的錯(cuò)誤觀念之一。就在幾天前,美國(guó)疾病控制與預(yù)防中心(CDC)推薦小學(xué)生接種輝瑞(Pfizer)的新冠疫苗,現(xiàn)在專家們擔(dān)心家長(zhǎng)因?yàn)檫@種荒誕說(shuō)法而無(wú)法在新冠疫情決勝階段邁出關(guān)鍵一步。

凱澤家族基金會(huì)(Kaiser Family Foundation)在最新的《新冠疫苗監(jiān)測(cè)報(bào)告》(COVID-19 Vaccine Monitor)中發(fā)布的一項(xiàng)調(diào)查顯示,在5-11歲孩子的家長(zhǎng)中,有三分之二表示他們不讓孩子接種新冠疫苗的原因是擔(dān)心孩子未來(lái)的生育能力。除此之外,自去年12月新冠疫苗首次獲得緊急使用授權(quán)以來(lái),各項(xiàng)研究表明這個(gè)荒誕說(shuō)法是人們不愿意接種新冠疫苗的主要原因。

佛羅里達(dá)大學(xué)(University of Florida)致力于新冠疫苗接種和妊娠研究的兒科醫(yī)生兼流行病學(xué)家索尼婭·拉斯穆森稱:“絕對(duì)沒(méi)有任何證據(jù)表明新冠疫苗會(huì)導(dǎo)致不孕癥?!彼硎?,已經(jīng)有數(shù)千人在接種新冠疫苗之后懷孕。此外,對(duì)接種新冠疫苗者展開(kāi)的大量研究證明,新冠疫苗接種對(duì)女性或男性的生育能力均沒(méi)有影響。多項(xiàng)研究也表明新冠疫苗對(duì)孕婦安全有效。

拉斯穆森毫不猶豫地向28歲的女兒和25歲的兒子推薦新冠疫苗。她說(shuō):“現(xiàn)有數(shù)據(jù)表明,這種新冠疫苗安全有效,年輕人可以接種。如果我擔(dān)心生育問(wèn)題或任何長(zhǎng)期影響的話,我絕不會(huì)在孩子們符合接種條件的那一刻就催促他們?nèi)ソ臃N新冠疫苗?!?/p>

盡管如此,全國(guó)各地的醫(yī)生也從患者那里聽(tīng)到這個(gè)荒誕說(shuō)法。一位密蘇里州的家庭醫(yī)生勞拉·莫里斯已經(jīng)聽(tīng)過(guò)太多次了,現(xiàn)在當(dāng)有未接種新冠疫苗的患者或未接種新冠疫苗的患者家屬前來(lái)就診時(shí),她會(huì)主動(dòng)提起這個(gè)荒誕說(shuō)法。

她表示:“有些患者和家長(zhǎng)非常想聽(tīng)聽(tīng)醫(yī)生的意見(jiàn)?!碑?dāng)她告訴他們這個(gè)荒誕說(shuō)法不是真的后,他們就放心了。其他人則對(duì)新冠疫苗的科學(xué)原理產(chǎn)生疑問(wèn),她會(huì)花時(shí)間向他們解釋清楚。

隨著有資格接種新冠疫苗的人群范圍擴(kuò)大到更年輕的患者,莫里斯發(fā)現(xiàn)她不得不替不同年齡段的人打消接種顧慮。在新冠疫情初期,向她提問(wèn)的大部分是女性,但是現(xiàn)在向她請(qǐng)教問(wèn)題的是青年男女的家長(zhǎng)們,他們已經(jīng)在為要孫子孫女做打算了。

正如每一條被人們所接納的虛假信息一樣,新冠疫苗接種導(dǎo)致不育癥這種錯(cuò)誤聯(lián)系始于不確定性。目前在美國(guó)獲授權(quán)的新冠疫苗均未同時(shí)在普通人群和孕婦身上進(jìn)行試驗(yàn)。這很正常:因?yàn)樵袐D是“藥物孤兒”。這個(gè)特定術(shù)語(yǔ)是指很少參與藥物試驗(yàn)的人群。但在此情況下,這就意味著2020年年末,醫(yī)生和民眾要努力在感染新冠肺炎的特定風(fēng)險(xiǎn)(對(duì)孕婦而言風(fēng)險(xiǎn)更大)和接種新冠疫苗帶來(lái)的潛在風(fēng)險(xiǎn)之間進(jìn)行權(quán)衡。

根據(jù)絕大多數(shù)專家的意見(jiàn),接種新冠疫苗是正確的選擇,數(shù)千名懷孕的醫(yī)護(hù)人員選擇了接種新冠疫苗。但是,直到2021年4月一項(xiàng)研究表明新冠疫苗對(duì)孕婦群體的安全性后,美國(guó)食品與藥品監(jiān)督管理局(FDA)才正式推薦孕婦接種新冠疫苗。

在此期間的幾個(gè)月時(shí)間內(nèi),一場(chǎng)關(guān)于輝瑞前副總裁變成反疫苗人士的謠言堪稱火上澆油。直到2011年,輝瑞德國(guó)公司過(guò)敏和呼吸研究部門(mén)的副總裁邁克爾·伊登聲稱,疫苗靶向的SARS-CoV-2刺突蛋白與在人類胚胎中發(fā)現(xiàn)的一種蛋白具有微小的相似性,當(dāng)接種新冠疫苗者的身體對(duì)胎盤(pán)產(chǎn)生排斥反應(yīng),可能會(huì)導(dǎo)致流產(chǎn)。他和一位同事于2020年12月1日致信歐洲藥品管理局(European Medicines Agency),他們?cè)谛胖幸笤摍C(jī)構(gòu)停止新冠疫苗試驗(yàn),因?yàn)檫@將“導(dǎo)致接種新冠疫苗的婦女基本失去生育能力”。

他的說(shuō)法已經(jīng)被揭穿。拉斯穆森說(shuō):“雖然有極小的一片區(qū)域相似,但這片區(qū)域的面積很小,小到人們肯定不會(huì)認(rèn)為它會(huì)對(duì)生育能力產(chǎn)生任何影響?!?/p>

邁阿密大學(xué)(University of Miami)的生殖泌尿科醫(yī)生蘭吉特·拉馬薩米表示,輝瑞公司和Moderna公司的原始試驗(yàn)均未對(duì)生殖毒性進(jìn)行評(píng)估,這又額外造成了一些不確定性。拉馬薩米曾經(jīng)研究新冠肺炎和不孕癥之間的聯(lián)系。同樣不足為奇的是:這些研究通常要到臨床試驗(yàn)的第三階段才會(huì)進(jìn)行,即使到那時(shí),也只有在預(yù)期孕婦會(huì)接種新冠疫苗的情況下才能夠進(jìn)行。

但對(duì)這些新冠疫苗可能導(dǎo)致不孕癥的猜想,從來(lái)不存在任何科學(xué)依據(jù)?,F(xiàn)在我們可以肯定新冠疫苗不會(huì)導(dǎo)致不孕癥。促使美國(guó)疾病控制與預(yù)防中心對(duì)孕婦提出建議的研究只是世界各地正在開(kāi)展的眾多研究之一,沒(méi)有一項(xiàng)研究表明新冠疫苗接種與流產(chǎn)或不孕癥之間存在任何聯(lián)系。對(duì)接種新冠疫苗后男性的研究,包括拉馬薩米撰寫(xiě)的一項(xiàng)研究,也取得了同樣的結(jié)果。

盡管如此,這個(gè)荒誕說(shuō)法仍然留存了下來(lái)并傳播開(kāi)來(lái)。拉馬薩米的研究發(fā)現(xiàn),在2020年12月美國(guó)疾病控制與預(yù)防中心緊急授權(quán)使用輝瑞-BioNTech的新冠疫苗后,谷歌(Google)上“新冠疫苗生育能力”等詞的搜索量在一個(gè)半月內(nèi)飆升了700%。

具有諷刺意味的是,雖然從未有人發(fā)現(xiàn)新冠疫苗對(duì)生育能力有影響,但人們已經(jīng)發(fā)現(xiàn)感染新冠肺炎對(duì)男性生育能力有顯著影響,盡管這方面仍然存在許多問(wèn)題尚未解答。感染新冠肺炎對(duì)孕婦來(lái)說(shuō)也危險(xiǎn)得多,并且與新冠病毒攜帶者和胚胎的一系列負(fù)面結(jié)果有關(guān),包括流產(chǎn)和早產(chǎn)。

肯塔基大學(xué)(University of Kentucky)婦產(chǎn)科專業(yè)的雷切爾·桑德斯說(shuō):“人們擔(dān)心不孕不育?!彼硎?,對(duì)生育能力感到擔(dān)憂是很正常的,這可能是這種荒誕的說(shuō)法留存下來(lái)的原因之一。

匹茲堡大學(xué)醫(yī)學(xué)院(University of Pittsburgh School of Medicine)的醫(yī)生兼內(nèi)科教授埃洛霍·烏福馬塔說(shuō):“感到害怕沒(méi)有錯(cuò)。憂慮和擔(dān)憂沒(méi)有錯(cuò)。”但是她指出:“我們了解有數(shù)十萬(wàn)人接種了新冠疫苗,并且成功懷孕?!?/p>

2020年12月底,處于妊娠第三期(一期為三個(gè)月)的烏福馬塔在接種了新冠疫苗后,把這一消息發(fā)布到了社交媒體上。最近在打了新冠疫苗加強(qiáng)針后,她又發(fā)了一次動(dòng)態(tài),鼓勵(lì)她的粉絲如果有問(wèn)題,可以和她取得聯(lián)系。

她收到并對(duì)何時(shí)接種新冠疫苗、流產(chǎn)風(fēng)險(xiǎn)和生育能力等問(wèn)題進(jìn)行了回答。她說(shuō):“作為一名黑人醫(yī)生和一名黑人婦女,我知道由于系統(tǒng)性的不公正,黑人婦女不信任醫(yī)療體系。我認(rèn)為有某個(gè)值得信任的人與他們進(jìn)行這些對(duì)話真的很重要,尤其是在懷孕期間?!?/p>

烏福馬塔認(rèn)為,把孕婦從新冠疫苗的試驗(yàn)中排除的做法是錯(cuò)誤的。她說(shuō):“它讓許多陰謀論大行其道,因?yàn)槿藗儫o(wú)法回答這些問(wèn)題。根據(jù)小道消息或沒(méi)有數(shù)據(jù)支持,醫(yī)生和科學(xué)家都不愿意回答這些問(wèn)題?!?/p>

這種荒誕說(shuō)法的傳播沒(méi)有減緩的跡象,名噪一時(shí)的誤傳者的言論肯定無(wú)濟(jì)于事。針對(duì)這一說(shuō)法,接受采訪的專家感到擔(dān)憂,尤其是為孕婦或可能懷孕的人以及兒童和青少年感到擔(dān)憂。

桑德斯說(shuō):“我們未看到接種新冠疫苗和不孕癥之間存在任何關(guān)聯(lián),但我們確實(shí)看到感染新冠肺炎對(duì)孕婦造成了非常大的負(fù)面影響?!?/p>

拉馬薩米從他的病人那里得知,其他醫(yī)生正在建議他們或他們的伴侶懷孕后再接種新冠疫苗,這讓他感到擔(dān)憂。他說(shuō):“醫(yī)生在接種新冠疫苗方面不應(yīng)該遲疑不決。”(財(cái)富中文網(wǎng))

翻譯:李亞男

審校:汪皓

11月5日,綠灣包裝工隊(duì)(Green Bay Packers)的四分衛(wèi)阿隆·羅杰斯告訴《帕特·麥卡菲秀》(Pat McAfee Show),他因?yàn)閾?dān)心患上不孕癥而拒絕接種新冠疫苗,由此他成為最近公開(kāi)表示擔(dān)心新冠疫苗接種和不育癥問(wèn)題的名人。羅杰斯說(shuō):“我相信,我人生的下一個(gè)重要篇章是成為一名父親,所以我對(duì)這件事情非常重視。”

羅杰斯并不是唯一有這種擔(dān)憂的人,但這并不意味著他的想法是對(duì)的。在這場(chǎng)為期近一年的新冠疫苗接種運(yùn)動(dòng)中,新冠疫苗影響生育能力的荒誕說(shuō)法是持續(xù)時(shí)間最久的錯(cuò)誤觀念之一。就在幾天前,美國(guó)疾病控制與預(yù)防中心(CDC)推薦小學(xué)生接種輝瑞(Pfizer)的新冠疫苗,現(xiàn)在專家們擔(dān)心家長(zhǎng)因?yàn)檫@種荒誕說(shuō)法而無(wú)法在新冠疫情決勝階段邁出關(guān)鍵一步。

凱澤家族基金會(huì)(Kaiser Family Foundation)在最新的《新冠疫苗監(jiān)測(cè)報(bào)告》(COVID-19 Vaccine Monitor)中發(fā)布的一項(xiàng)調(diào)查顯示,在5-11歲孩子的家長(zhǎng)中,有三分之二表示他們不讓孩子接種新冠疫苗的原因是擔(dān)心孩子未來(lái)的生育能力。除此之外,自去年12月新冠疫苗首次獲得緊急使用授權(quán)以來(lái),各項(xiàng)研究表明這個(gè)荒誕說(shuō)法是人們不愿意接種新冠疫苗的主要原因。

佛羅里達(dá)大學(xué)(University of Florida)致力于新冠疫苗接種和妊娠研究的兒科醫(yī)生兼流行病學(xué)家索尼婭·拉斯穆森稱:“絕對(duì)沒(méi)有任何證據(jù)表明新冠疫苗會(huì)導(dǎo)致不孕癥?!彼硎?,已經(jīng)有數(shù)千人在接種新冠疫苗之后懷孕。此外,對(duì)接種新冠疫苗者展開(kāi)的大量研究證明,新冠疫苗接種對(duì)女性或男性的生育能力均沒(méi)有影響。多項(xiàng)研究也表明新冠疫苗對(duì)孕婦安全有效。

拉斯穆森毫不猶豫地向28歲的女兒和25歲的兒子推薦新冠疫苗。她說(shuō):“現(xiàn)有數(shù)據(jù)表明,這種新冠疫苗安全有效,年輕人可以接種。如果我擔(dān)心生育問(wèn)題或任何長(zhǎng)期影響的話,我絕不會(huì)在孩子們符合接種條件的那一刻就催促他們?nèi)ソ臃N新冠疫苗。”

盡管如此,全國(guó)各地的醫(yī)生也從患者那里聽(tīng)到這個(gè)荒誕說(shuō)法。一位密蘇里州的家庭醫(yī)生勞拉·莫里斯已經(jīng)聽(tīng)過(guò)太多次了,現(xiàn)在當(dāng)有未接種新冠疫苗的患者或未接種新冠疫苗的患者家屬前來(lái)就診時(shí),她會(huì)主動(dòng)提起這個(gè)荒誕說(shuō)法。

她表示:“有些患者和家長(zhǎng)非常想聽(tīng)聽(tīng)醫(yī)生的意見(jiàn)?!碑?dāng)她告訴他們這個(gè)荒誕說(shuō)法不是真的后,他們就放心了。其他人則對(duì)新冠疫苗的科學(xué)原理產(chǎn)生疑問(wèn),她會(huì)花時(shí)間向他們解釋清楚。

隨著有資格接種新冠疫苗的人群范圍擴(kuò)大到更年輕的患者,莫里斯發(fā)現(xiàn)她不得不替不同年齡段的人打消接種顧慮。在新冠疫情初期,向她提問(wèn)的大部分是女性,但是現(xiàn)在向她請(qǐng)教問(wèn)題的是青年男女的家長(zhǎng)們,他們已經(jīng)在為要孫子孫女做打算了。

正如每一條被人們所接納的虛假信息一樣,新冠疫苗接種導(dǎo)致不育癥這種錯(cuò)誤聯(lián)系始于不確定性。目前在美國(guó)獲授權(quán)的新冠疫苗均未同時(shí)在普通人群和孕婦身上進(jìn)行試驗(yàn)。這很正常:因?yàn)樵袐D是“藥物孤兒”。這個(gè)特定術(shù)語(yǔ)是指很少參與藥物試驗(yàn)的人群。但在此情況下,這就意味著2020年年末,醫(yī)生和民眾要努力在感染新冠肺炎的特定風(fēng)險(xiǎn)(對(duì)孕婦而言風(fēng)險(xiǎn)更大)和接種新冠疫苗帶來(lái)的潛在風(fēng)險(xiǎn)之間進(jìn)行權(quán)衡。

根據(jù)絕大多數(shù)專家的意見(jiàn),接種新冠疫苗是正確的選擇,數(shù)千名懷孕的醫(yī)護(hù)人員選擇了接種新冠疫苗。但是,直到2021年4月一項(xiàng)研究表明新冠疫苗對(duì)孕婦群體的安全性后,美國(guó)食品與藥品監(jiān)督管理局(FDA)才正式推薦孕婦接種新冠疫苗。

在此期間的幾個(gè)月時(shí)間內(nèi),一場(chǎng)關(guān)于輝瑞前副總裁變成反疫苗人士的謠言堪稱火上澆油。直到2011年,輝瑞德國(guó)公司過(guò)敏和呼吸研究部門(mén)的副總裁邁克爾·伊登聲稱,疫苗靶向的SARS-CoV-2刺突蛋白與在人類胚胎中發(fā)現(xiàn)的一種蛋白具有微小的相似性,當(dāng)接種新冠疫苗者的身體對(duì)胎盤(pán)產(chǎn)生排斥反應(yīng),可能會(huì)導(dǎo)致流產(chǎn)。他和一位同事于2020年12月1日致信歐洲藥品管理局(European Medicines Agency),他們?cè)谛胖幸笤摍C(jī)構(gòu)停止新冠疫苗試驗(yàn),因?yàn)檫@將“導(dǎo)致接種新冠疫苗的婦女基本失去生育能力”。

他的說(shuō)法已經(jīng)被揭穿。拉斯穆森說(shuō):“雖然有極小的一片區(qū)域相似,但這片區(qū)域的面積很小,小到人們肯定不會(huì)認(rèn)為它會(huì)對(duì)生育能力產(chǎn)生任何影響?!?/p>

邁阿密大學(xué)(University of Miami)的生殖泌尿科醫(yī)生蘭吉特·拉馬薩米表示,輝瑞公司和Moderna公司的原始試驗(yàn)均未對(duì)生殖毒性進(jìn)行評(píng)估,這又額外造成了一些不確定性。拉馬薩米曾經(jīng)研究新冠肺炎和不孕癥之間的聯(lián)系。同樣不足為奇的是:這些研究通常要到臨床試驗(yàn)的第三階段才會(huì)進(jìn)行,即使到那時(shí),也只有在預(yù)期孕婦會(huì)接種新冠疫苗的情況下才能夠進(jìn)行。

但對(duì)這些新冠疫苗可能導(dǎo)致不孕癥的猜想,從來(lái)不存在任何科學(xué)依據(jù)。現(xiàn)在我們可以肯定新冠疫苗不會(huì)導(dǎo)致不孕癥。促使美國(guó)疾病控制與預(yù)防中心對(duì)孕婦提出建議的研究只是世界各地正在開(kāi)展的眾多研究之一,沒(méi)有一項(xiàng)研究表明新冠疫苗接種與流產(chǎn)或不孕癥之間存在任何聯(lián)系。對(duì)接種新冠疫苗后男性的研究,包括拉馬薩米撰寫(xiě)的一項(xiàng)研究,也取得了同樣的結(jié)果。

盡管如此,這個(gè)荒誕說(shuō)法仍然留存了下來(lái)并傳播開(kāi)來(lái)。拉馬薩米的研究發(fā)現(xiàn),在2020年12月美國(guó)疾病控制與預(yù)防中心緊急授權(quán)使用輝瑞-BioNTech的新冠疫苗后,谷歌(Google)上“新冠疫苗生育能力”等詞的搜索量在一個(gè)半月內(nèi)飆升了700%。

具有諷刺意味的是,雖然從未有人發(fā)現(xiàn)新冠疫苗對(duì)生育能力有影響,但人們已經(jīng)發(fā)現(xiàn)感染新冠肺炎對(duì)男性生育能力有顯著影響,盡管這方面仍然存在許多問(wèn)題尚未解答。感染新冠肺炎對(duì)孕婦來(lái)說(shuō)也危險(xiǎn)得多,并且與新冠病毒攜帶者和胚胎的一系列負(fù)面結(jié)果有關(guān),包括流產(chǎn)和早產(chǎn)。

肯塔基大學(xué)(University of Kentucky)婦產(chǎn)科專業(yè)的雷切爾·桑德斯說(shuō):“人們擔(dān)心不孕不育?!彼硎?,對(duì)生育能力感到擔(dān)憂是很正常的,這可能是這種荒誕的說(shuō)法留存下來(lái)的原因之一。

匹茲堡大學(xué)醫(yī)學(xué)院(University of Pittsburgh School of Medicine)的醫(yī)生兼內(nèi)科教授埃洛霍·烏福馬塔說(shuō):“感到害怕沒(méi)有錯(cuò)。憂慮和擔(dān)憂沒(méi)有錯(cuò)。”但是她指出:“我們了解有數(shù)十萬(wàn)人接種了新冠疫苗,并且成功懷孕?!?/p>

2020年12月底,處于妊娠第三期(一期為三個(gè)月)的烏福馬塔在接種了新冠疫苗后,把這一消息發(fā)布到了社交媒體上。最近在打了新冠疫苗加強(qiáng)針后,她又發(fā)了一次動(dòng)態(tài),鼓勵(lì)她的粉絲如果有問(wèn)題,可以和她取得聯(lián)系。

她收到并對(duì)何時(shí)接種新冠疫苗、流產(chǎn)風(fēng)險(xiǎn)和生育能力等問(wèn)題進(jìn)行了回答。她說(shuō):“作為一名黑人醫(yī)生和一名黑人婦女,我知道由于系統(tǒng)性的不公正,黑人婦女不信任醫(yī)療體系。我認(rèn)為有某個(gè)值得信任的人與他們進(jìn)行這些對(duì)話真的很重要,尤其是在懷孕期間。”

烏福馬塔認(rèn)為,把孕婦從新冠疫苗的試驗(yàn)中排除的做法是錯(cuò)誤的。她說(shuō):“它讓許多陰謀論大行其道,因?yàn)槿藗儫o(wú)法回答這些問(wèn)題。根據(jù)小道消息或沒(méi)有數(shù)據(jù)支持,醫(yī)生和科學(xué)家都不愿意回答這些問(wèn)題?!?/p>

這種荒誕說(shuō)法的傳播沒(méi)有減緩的跡象,名噪一時(shí)的誤傳者的言論肯定無(wú)濟(jì)于事。針對(duì)這一說(shuō)法,接受采訪的專家感到擔(dān)憂,尤其是為孕婦或可能懷孕的人以及兒童和青少年感到擔(dān)憂。

桑德斯說(shuō):“我們未看到接種新冠疫苗和不孕癥之間存在任何關(guān)聯(lián),但我們確實(shí)看到感染新冠肺炎對(duì)孕婦造成了非常大的負(fù)面影響?!?/p>

拉馬薩米從他的病人那里得知,其他醫(yī)生正在建議他們或他們的伴侶懷孕后再接種新冠疫苗,這讓他感到擔(dān)憂。他說(shuō):“醫(yī)生在接種新冠疫苗方面不應(yīng)該遲疑不決?!保ㄘ?cái)富中文網(wǎng))

翻譯:李亞男

審校:汪皓

On November 5, Green Bay Packers quarterback Aaron Rodgers became the latest celebrity to express concern about COVID-19 vaccination and infertility, when he told the Pat McAfee Show that he avoided the vaccine because of worries over sterility. “The next great chapter of my life, I believe, is being a father and it’s something that I care about a lot,” Rodgers said.

Rodgers isn’t alone in his worries, but that doesn’t mean he’s right. The fertility myth has been one of the most persistent misconceptions dogging this almost year-long vaccination campaign. Now, just days after Pfizer’s vaccine was recommended by the CDC for elementary-aged children, experts are concerned that the myth will prevent parents from taking this crucial step in ending the pandemic.

Two thirds of parents of 5 to 11 year olds cited concerns about their children’s future fertility as reasons for not vaccinating, in a survey published in the Kaiser Family Foundation’s most recent COVID-19 Vaccine Monitor. In addition, studies since the vaccines were first granted Emergency Use Authorization last December have shown that this myth has been a key motivator for people to not get vaccinated.

“There’s absolutely no evidence that the vaccines cause infertility,” says Sonja Rasmussen, a University of Florida pediatrician and epidemiologist who studies COVID-19 vaccination and pregnancy. Thousands of people have gotten pregnant since being vaccinated, she says. In addition, numerous studies of vaccinated people have demonstrated that COVID-19 vaccination has no impact on either female or male fertility. Multiple studies have shown that the vaccine is safe and effective in pregnant people.

Rasmussen had no hesitation in recommending the vaccine to her own 28-year-old daughter and 25-year-old son. “The data we have right now has shown that young people can receive this vaccine, that it’s safe, and that it is effective,” she says. “There’s no way, if I had concerns about fertility or any long term effects, that I’d have pushed my kids to get the vaccine the minute they were eligible.”

Still, doctors around the country are encountering this myth among their patients. Laura Morris, a family physician who practices in Missouri, has heard about it so many times that she now proactively brings it up when unvaccinated patients or their unvaccinated family members come in.

“There’s a group of patients and parents that really want to hear from their doctor,” she says. Once they’ve heard from her that there’s no reality to this myth, they’re reassured. Others have questions about the science behind the vaccine, and she spends time explaining it to them.

As vaccine eligibility has been expanded to ever-younger patients, Morris finds herself having to address concerns about vaccination for people at different stages of life. Earlier in the pandemic most of her questions came from women, but she’s now talking to parents of young boys and girls who are already thinking about grandchildren.

As with every successful piece of false information, the untrue link between vaccination and infertility began with uncertainty. None of the COVID-19 vaccines currently authorized in the United States were trialed on pregnant people at the same time as the general population. That’s normal: pregnant people are “drug orphans,” a term of art for populations who are rarely part of drug trials. But in this case, it did mean that at the end of 2020 doctors and the public found themselves trying to weigh the certain risk of getting COVID-19, which is more severe for pregnant people, against the possible risk of a vaccine.

Expert opinion overwhelmingly suggested that vaccination was the right choice, and the case built as thousands of pregnant healthcare workers opted to be vaccinated. But it wasn’t until April 2021 that the FDA formally recommended the vaccine for pregnant people after a study demonstrated its safety in that population.

In the intervening months, a rumor began by an ex-Pfizer VP turned anti-vaxxer helped to stoke a wildfire. Michael Yeadon, who was the vice president of the German company’s allergy and respiratory research division until 2011, claimed that a tiny similarity between the SARS-CoV-2 spike protein that the vaccines target and a protein found in the human placenta could result in vaccinated people having miscarriages when their body attacked the placenta. This would “result in vaccinated women essentially becoming infertile,” he and a colleague wrote in a December 1, 2020 letter to the European Medicines Agency that asked it to stop trialing the vaccines.

His claims have been debunked. “There is a little tiny area that’s similar,” Rasmussen says, “but certainly not any amount that would make you think it would have any effect on fertility.”

An additional piece of uncertainty was caused by the fact that neither Pfizer nor Moderna’s original trials evaluated reproductive toxicity, says Ranjith Ramasamy, a University of Miami reproductive urologist who has studied the links between COVID-19 and infertility. Again, that’s not unusual: These studies are normally not conducted until Phase 3 of clinical trials, and even then only if it’s expected that pregnant women will be taking the vaccine.

But there was never any scientific reason to suspect that these vaccines could cause infertility. Now we know for sure that they don’t. The study that prompted the CDC to make its recommendation for pregnant women is just one of many going on around the world, none of which have shown there to be any link between COVID-19 vaccination and pregnancy loss or infertility. Studies of men after vaccination, including one authored by Ramasamy, have found the same.

Still, the myth persisted and spread. Google searches for terms like “COVID vaccine fertility” spiked by as much as 700% in the month and a half following the CDC’s emergency authorization for the Pfizer-BioNTech vaccine in December 2020, Ramasamy’s research found.

The irony here is that while the vaccines have never been found to impact fertility, COVID-19 infection has been found to significantly impact male fertility, although there are still many unanswered questions. A COVID-19 infection is also much, much more dangerous for pregnant people, and is associated with a host of negative outcomes for both carrier and fetus, including miscarriage and preterm birth.

“Infertility is something people worry about anyways,” says Rachel Saunders, a University of Kentucky OBGYN. It’s very normal to have concerns about fertility, she says, and that may be one of the reasons why this myth has stuck around.

“It’s not wrong to feel scared,” says Eloho Ufomata, a doctor and professor of internal medicine at the University of Pittsburgh School of Medicine. “It’s not wrong to have concerns and worries.” But “we know that hundreds of thousands of people have gotten vaccinated and have had successful pregnancies,” she says.

Ufomata, who is in her third trimester, posted on social media when she got vaccinated at the end of December 2020—and again recently when she received her booster shot—encouraging her followers to get in touch if they have questions.

She has fielded questions about when to get vaccinated, the risk of pregnancy loss, and fertility. “As a Black physician and as a Black woman, I know about the distrust of the medical system that Black women have due to systemic injustices,” she says. “I think it’s really important, especially during pregnancy, to have someone you trust, and to have these conversations with them.”

Ufomata feels it was a mistake to not include pregnant women in trials of the COVID-19 vaccines. “It allowed a lot of conspiracy theories to flourish, because there was no way to answer those questions,” she says. “And physicians and scientists are very hesitant to answer questions anecdotally or without data.”

This myth shows no signs of slowing its spread and remarks by prominent misinformers are certainly not helping. The experts interviewed for this story are concerned, especially for pregnant people or those who might get pregnant and for children and teens.

“We don’t see any correlation between getting the vaccine and having issues with infertility,” Saunders says, “but we do see very negative effects for pregnant people getting COVID-19.”

Ramasamy is also concerned by reports from his patients that other physicians are counseling them or their partner to wait on COVID-19 vaccination until after pregnancy. “There should be no hesitancy on the physician’s part,” he says.

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